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gabP [2018-02-13T08:58:43.000Z]
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gabP [2018-02-13T08:58:43.000Z]

gamma-amino butyric acid permease and minor proline permease
locus
BSU06310
pI
9.45
mw
50.93 kDa
protein length
469 aa Sequence Blast
gene length
1407 bp Sequence Blast
function
utilization of gamma-amino butyric acid
product
gamma-amino butyric acid permease
essential
no
synonyms
nrg-21
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.4|APC superfamily]
  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.4|Transporter for organic acids]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.10|Utilization of gamma-amino butyric acid]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    685,155 → 686,564

    Phenotypes of a mutant

  • defective in the utilization of gamma-amino butyrate [Pubmed|24142252]

    • The protein

    Catalyzed reaction/ biological activity

  • uptake of gamma-amino butyrate [Pubmed|24142252]
  • minor transporter for proline (allows growth with proline in the absence of the major [SW|transporters] [protein|B3DF99B747D0A7472E3878920BF3CE7CE954B0BE|PutP] and [protein|6A1F759DAC09D364602460E5467E2761E97CE45C|OpuE]) [Pubmed|24142252]

    • Paralogous protein(s)

  • [protein|CE4A49F5CCC2D36C5CE5AD7AE7F0A70F2D4F425C|AapA], [protein|423AEC9D260BE53AD22851D999244B89BEB3E84D|HutM], [protein|9BFB16C12B31ABD70BBB921BCB9E4201E3BDC92D|RocC], [protein|B46A8BCEC56E6252712E30F8BF8DA6B836FDE2F6|RocE], [protein|B6A920650919D5BBBD75CCA58C30A0D8ECE64DA3|YbgF], [protein|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|YbxG], [protein|C7FEA1D9C7C96C39CEE83CE3F13D412DE6AFE10E|YdgF], [protein|219586A3F378DC38EA076FD39B99D41136BDE722|YtnA], [protein|8C4A8961B2514A8AD531AFB104B10C0797D02AC2|YvbW]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP]
    description
    [Pubmed|8951816]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8951816], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|TnrA]: activation, [Pubmed|8951816], in [regulon|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|TnrA regulon]
  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|8951816], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]

    • regulation

  • expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|8951816]
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    Biological materials

    Mutant

  • available in [SW|Erhard Bremer]'s lab [Pubmed|24142252]
  • BKE06310 (Δ[gene|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE06310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTTACCTCCTTTTAA, downstream forward: _UP4_TAATGCTGATCAAATCCTAA
  • BKK06310 (Δ[gene|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK06310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTTACCTCCTTTTAA, downstream forward: _UP4_TAATGCTGATCAAATCCTAA

    • References

  • 8951816,9677314,24142252,25755103